Histidine is the only common amino acid with a side chain pKa near physiological pH, which is why it buffers biologically. In free GHK the imidazole would accept a proton at mildly acidic pH and release it as pH rises.
This is textbook amino acid chemistry.
Binding copper occupies the imidazole nitrogen and stabilises the deprotonated form, so the effective pKa shifts down. Copper also promotes deprotonation of the adjacent amide nitrogen, normally impossible near neutral pH, which is how the three-nitrogen chelate forms. Lowering pH reverses both: protons compete with copper and win below a threshold.
That threshold is the acid limit of the complex.
A GHK-Cu solution without added buffer settles at a pH set by the complex, its counterion and the water, and holds it weakly. Where the pH ends up determines whether the copper stays bound. This describes the chemistry; it specifies nothing about preparation.
GHK-Cu is supplied by REVIVE LAB UAE for laboratory research use only, with identity by mass spectrometry and purity by HPLC for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| GHK-Cu Pack | 50 mg | AED 425 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
Histidine is the only common amino acid with a side chain pKa near physiological pH, which is why it buffers biologically. In free GHK the imidazole would accept a proton at mildly acidic pH and release it as pH rises.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.