They arose by duplication and are highly similar in sequence, which is why their products share the four-helix fold. Only GH1 is active in the pituitary; the other four are expressed in placental tissue. CSHL1 is a pseudogene-like member with little or no functional product.
The cluster was characterised in the early 1980s as the genes were cloned.
Use of an alternative splice acceptor within exon 3 of GH1 removes fifteen residues, giving a 176-residue protein of about 20 kDa. It makes up a minority of pituitary secretion. Recombinant somatropin, expressed from a complementary DNA of the full-length message, contains none of it — the fact the isoform detection method relies on.
DeNoto and colleagues described the alternative splicing in 1981.
GH2 product binds the same receptor and is what the placenta uses to shift maternal metabolism. It is the reason growth hormone assays in pregnancy read differently, and it illustrates that the gene family encodes several hormones of overlapping function.
Somatropin is supplied by REVIVE LAB UAE for laboratory research use only, with identity and purity documented for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| HGH Somatropin Pack | 24 mg (72 IU) | AED 850 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
They arose by duplication and are highly similar in sequence, which is why their products share the four-helix fold. Only GH1 is active in the pituitary; the other four are expressed in placental tissue. CSHL1 is a pseudogene-like member with little or no functional product.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.