The 1968 study that tied the largest growth hormone pulse to slow-wave sleep

Published 26 October 2026 · REVIVE LAB UAE Research Desk · 5 min read
Takahashi, Kipnis and Daughaday, publishing in the Journal of Clinical Investigation in 1968, sampled blood through the night in healthy adults with simultaneous sleep recording and found a large growth hormone pulse beginning within the first hour of sleep, coinciding with the first period of slow-wave sleep. Delaying sleep delayed the pulse; waking subjects abolished it. Later work confirmed that in young men the majority of the daily output occurs in this pulse and that the amplitude of slow-wave sleep and of the pulse decline together with age.

The 1968 study

Eight subjects, frequent sampling through an indwelling catheter so as not to wake them, and electroencephalographic staging of sleep. The pulse appeared reliably in the first slow-wave period and recurred in smaller form with later ones. Shifting sleep to the daytime shifted the pulse, showing the link was to sleep rather than to the clock.

It was among the first demonstrations that a hormone was gated by sleep stage.

What came after

Pharmacological enhancement of slow-wave sleep increases the pulse; suppression reduces it. The releasing hormone itself promotes slow-wave sleep in some studies, suggesting a shared hypothalamic mechanism. With ageing, slow-wave sleep and the nocturnal pulse diminish in parallel, and the proportion of daily secretion occurring in sleep falls. These are correlations with a plausible mechanism, not fully resolved causation.

The Tesamorelin pages on this site cite the sleep literature for the releasing-hormone analogue.

Why it is here

Because the timing of secretion is part of the established physiology of the hormone in the pack. This page describes it; it recommends nothing.

Somatropin is supplied by REVIVE LAB UAE for laboratory research use only, with identity and purity documented for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.

What it costs

FormatStrengthPriceAvailability
HGH Somatropin Pack24 mg (72 IU)AED 850In stock

Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.

Frequently asked

The 1968 study?

Eight subjects, frequent sampling through an indwelling catheter so as not to wake them, and electroencephalographic staging of sleep. The pulse appeared reliably in the first slow-wave period and recurred in smaller form with later ones. Shifting sleep to the daytime shifted the pulse, showing the link was to sleep rather than to the clock.

Does REVIVE LAB UAE provide dosing guidance?

No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.

How fast is delivery in the UAE?

Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.

HGH Somatropin Pack — in stock, dispatched from Dubai
HPLC-verified, lot certificate on every carton, 24-hour delivery nationwide. Browse the catalogue → All peptides UAE

Related reading

Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.