The insulin family is ancient and its receptor-binding chemistry tightly constrained; mutations that alter binding are selected against. Across mammals the IGF-1 sequence varies mainly at positions away from the receptor and binding-protein surfaces. Even between humans and chickens the identity is high. Insulin itself is similarly conserved, which is why animal insulin treated human diabetes for sixty years.
IGF-2 is comparably conserved.
Growth hormone evolved rapidly in the primate lineage, and the primate receptor acquired a residue that excludes non-primate hormone. The hormone and receptor co-evolved into a species-specific pair. IGF-1 and its receptor did not, so the same ligand serves across the class. The two hormones, one step apart in the axis, have opposite evolutionary histories.
This is why the pituitary-extraction era was necessary for growth hormone and never arose for IGF-1.
Rodent results with human IGF-1 or its analogues reflect the human receptor pharmacology faithfully in a way rodent results with human growth hormone also do, but for a different reason — human growth hormone happens to act on rodent receptors while rodent growth hormone does not act on human ones. Species of ligand matters less for IGF-1 than for almost any other hormone.
IGF-1 LR3 is supplied by REVIVE LAB UAE for laboratory research use only, with identity and purity documented for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| IGF-1 LR3 Pack | 1 mg | AED 650 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
The insulin family is ancient and its receptor-binding chemistry tightly constrained; mutations that alter binding are selected against. Across mammals the IGF-1 sequence varies mainly at positions away from the receptor and binding-protein surfaces. Even between humans and chickens the identity is high. Insulin itself is similarly conserved, which is why animal insulin treated human diabetes for sixty years.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.