A small number of healthy volunteers received intravenous recombinant IGF-1 or insulin on separate occasions under observation, with glucose, insulin, fatty acids and other metabolites measured. The hypoglycaemic effect of IGF-1 was clear, slower in onset than insulin and lasting longer, consistent with its binding to the binding proteins and its action through its own receptor and the insulin receptor.
Zurich had been a centre of IGF research since the somatomedin era, and this group named the molecules insulin-like growth factors.
The hypoglycaemia became the dose-limiting effect in every therapeutic trial of IGF-1 and the principal safety concern for mecasermin. It is also the effect that the Adelaide rat studies found exaggerated with LR3, because free analogue reaches the receptors that bound IGF-1 cannot. The 1987 study is the human anchor for the hypoglycaemia page on this site.
The potency ratio to insulin has been reproduced in later work.
Because it is the first human experiment with the molecule the analogue is built on, and its result is the one that most constrains the whole field. This page describes a study; it describes no use of the pack.
IGF-1 LR3 is supplied by REVIVE LAB UAE for laboratory research use only, with identity and purity documented for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| IGF-1 LR3 Pack | 1 mg | AED 650 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
A small number of healthy volunteers received intravenous recombinant IGF-1 or insulin on separate occasions under observation, with glucose, insulin, fatty acids and other metabolites measured. The hypoglycaemic effect of IGF-1 was clear, slower in onset than insulin and lasting longer, consistent with its binding to the binding proteins and its action through its own receptor and the insulin receptor.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.