FOXO1, FOXO3, FOXO4 and FOXO6 in mammals; one, daf-16, in worms. Akt phosphorylation creates binding sites for 14-3-3 proteins that hold FOXO in the cytoplasm. When IGF-1 or insulin signalling falls, FOXO is dephosphorylated, returns to the nucleus and activates its targets. It is a binary-looking switch with graded reality: partial signalling gives partial exclusion.
Other inputs — AMPK, oxidative stress — also regulate FOXO, so it integrates several signals.
Antioxidant enzymes such as manganese superoxide dismutase and catalase; DNA repair genes; autophagy genes; the muscle atrophy genes atrogin-1 and MuRF1; gluconeogenic and lipid genes in liver; IGFBP-1. The last is why insulin suppresses IGFBP-1 and the atrophy genes are why IGF-1 preserves muscle: both are FOXO targets turned off by the same pathway.
The muscle maintenance and the longevity effects run through the same factor in opposite directions.
Because it is the molecular explanation for the trade-off the longevity page describes and for the muscle effects the Musarò page describes. It is pathway biology, stated as such.
IGF-1 LR3 is supplied by REVIVE LAB UAE for laboratory research use only, with identity and purity documented for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| IGF-1 LR3 Pack | 1 mg | AED 650 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
FOXO1, FOXO3, FOXO4 and FOXO6 in mammals; one, daf-16, in worms. Akt phosphorylation creates binding sites for 14-3-3 proteins that hold FOXO in the cytoplasm. When IGF-1 or insulin signalling falls, FOXO is dephosphorylated, returns to the nucleus and activates its targets. It is a binary-looking switch with graded reality: partial signalling gives partial exclusion.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.