The A domain contributes to the receptor-binding face. A sulfoxide at 59 is more polar and bulkier than the thioether and perturbs that face, which is why the oxidised form is less active rather than merely different. Somatropin, by comparison, has three methionines and its oxidised forms are less affected in activity.
A single oxidation site makes the degradation easy to quantify.
Dissolved oxygen, trace peroxide in excipients and light-generated radicals all oxidise methionine. The reaction is slow in the dry solid and faster in solution. Reversed-phase chromatography resolves the oxidised form as an earlier peak; intact mass shows the sixteen-dalton shift; peptide mapping places it at the residue.
Protect-from-light storage on the pack addresses one of the drivers.
Reported within related substances by the chromatographic method. A batch figure for oxidised form is part of describing the lot as released.
IGF-1 LR3 is supplied by REVIVE LAB UAE for laboratory research use only, with identity and purity documented for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| IGF-1 LR3 Pack | 1 mg | AED 650 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
The A domain contributes to the receptor-binding face. A sulfoxide at 59 is more polar and bulkier than the thioether and perturbs that face, which is why the oxidised form is less active rather than merely different. Somatropin, by comparison, has three methionines and its oxidised forms are less affected in activity.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.