Small cysteine-rich proteins express poorly in bacteria on their own and are often degraded. Fusing them to a short peptide or a larger partner stabilises them and increases yield. The Adelaide work used a short leader and found that the fusion product, after refolding, was itself active.
Removing the leader would have added a cleavage step and cost yield; keeping it gave a product with a property of its own.
The binding proteins contact IGF-1 near its amino terminus. An extension there, together with the arginine at position 3, lowers binding-protein affinity substantially while leaving receptor binding largely intact. In cell culture, where binding proteins secreted by the cells would otherwise sequester added IGF-1, that made the analogue more potent per unit added than the native protein.
This is the whole rationale for the molecule and the reason it became a standard media supplement.
The product is defined by 83 residues, with the extension sequence and the arginine both part of the expected mass. A certificate confirming intact mass confirms both. Native IGF-1, at 70 residues, is a different molecule with a different mass and is not what the pack contains.
IGF-1 LR3 is supplied by REVIVE LAB UAE for laboratory research use only, with identity and purity documented for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| IGF-1 LR3 Pack | 1 mg | AED 650 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
Small cysteine-rich proteins express poorly in bacteria on their own and are often degraded. Fusing them to a short peptide or a larger partner stabilises them and increases yield. The Adelaide work used a short leader and found that the fusion product, after refolding, was itself active.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.