An adeno-associated virus carrying the IGF-1 gene was injected into the muscles of young and old mice. Injected muscles were about 15 per cent larger and stronger in young animals, and in old animals the usual decline in mass and strength was prevented, with the treated muscles matching those of young mice. Circulating IGF-1 was unchanged, so the effect was local.
The authors noted the implications for muscle disease and for ageing, and the study was widely cited in both contexts.
The mIGF-1 construct used a muscle-specific promoter and an isoform that stays in the tissue. Mice showed hypertrophy from youth, maintained it into old age, and regenerated muscle after injury better than controls. Serum IGF-1 was normal, and the mice did not show the systemic effects of circulating excess. The same construct later protected muscle in a mouse model of muscular dystrophy.
It is the clearest demonstration that where IGF-1 acts determines what it does.
That IGF-1 in muscle is anabolic and protective in mice when expressed there continuously by the muscle itself. That is not evidence about an analogue delivered from outside, which reaches every tissue and does not stay local. The pack is a research material.
IGF-1 LR3 is supplied by REVIVE LAB UAE for laboratory research use only, with identity and purity documented for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| IGF-1 LR3 Pack | 1 mg | AED 650 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
An adeno-associated virus carrying the IGF-1 gene was injected into the muscles of young and old mice. Injected muscles were about 15 per cent larger and stronger in young animals, and in old animals the usual decline in mass and strength was prevented, with the treated muscles matching those of young mice. Circulating IGF-1 was unchanged, so the effect was local.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.