The compounds raised oxidative gene expression and endurance in sedentary mice and, for AICAR, did so without training. The authors framed the result as pharmacological activation of a training programme. GW501516 was later abandoned for toxicity and both compounds were placed on the anti-doping list in the metabolic modulator class. The idea outlived the compounds.
The paper remains among the most cited in exercise biochemistry.
Exercise is a whole-body stimulus with hundreds of signalling changes across tissues; its benefits for cardiovascular disease, cancer, cognition and mortality are not reducible to AMPK in muscle. A drug that activates one node may reproduce one adaptation and miss or oppose others. Critics also note that mouse treadmill endurance is a narrow endpoint and that the term invites misuse as a substitute for activity. Proponents reply that the term was always meant narrowly.
The disagreement is partly about the word and partly about the biology.
The 2021 mouse data support a muscle-performance effect in mice. The label exercise mimetic attaches to that and to the AMPK mechanism. It should not be read as a statement that the peptide reproduces exercise, in mice or in anyone. The pack is a research material.
MOTS-c is supplied by REVIVE LAB UAE for laboratory research use only, with identity by mass spectrometry and purity by HPLC for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| MOTS-c Pack | 40 mg | AED 950 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
The compounds raised oxidative gene expression and endurance in sedentary mice and, for AICAR, did so without training. The authors framed the result as pharmacological activation of a training programme. GW501516 was later abandoned for toxicity and both compounds were placed on the anti-doping list in the metabolic modulator class. The idea outlived the compounds.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.