Where each kind of MOTS-c evidence comes from, and how much of each there is

Published 26 October 2026 · REVIVE LAB UAE Research Desk · 5 min read
Mechanistic work on MOTS-c — the folate and AMPK route, nuclear translocation, gene regulation — is from cultured cells. Physiological effects — on body weight, insulin sensitivity, exercise capacity, and ageing phenotypes — are from mice, in the 2015 paper and in later studies including the 2021 exercise work. Human data consist of cross-sectional measurements of circulating levels, the exercise-induced rise in young men, the K14Q polymorphism associations in Japanese cohorts, and the CB4211 phase 1 of a modified analogue. No controlled study of the native peptide in humans has been published.

Cells

Metabolomics, AMPK phosphorylation, chromatin binding, gene expression and cytoprotection assays, in muscle cell lines, adipocytes and others. This is where the mechanisms were proposed and is the strongest part of the record for mechanism and the weakest for physiological relevance.

Concentrations used in culture are not translatable to any other setting.

Mice

Prevention of diet-induced obesity and insulin resistance in the 2015 paper; improved performance and healthspan measures in young, middle-aged and old mice in the 2021 paper; and a scattering of studies in disease models since. Effects are consistent in direction. Mice differ from humans in metabolism, and mouse MOTS-c differs from human MOTS-c in sequence.

This is the bulk of the published literature.

Humans

Observational and small. The polymorphism data are genetic associations. The exercise data are a rise in an endogenous peptide after exertion. The phase 1 was of an analogue, in a handful of participants, reported by the sponsor. Each is real and each is limited, and together they do not amount to evidence that administering the peptide does anything in people. The catalogue states none.

MOTS-c is supplied by REVIVE LAB UAE for laboratory research use only, with identity by mass spectrometry and purity by HPLC for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.

What it costs

FormatStrengthPriceAvailability
MOTS-c Pack40 mgAED 950In stock

Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.

Frequently asked

Cells?

Metabolomics, AMPK phosphorylation, chromatin binding, gene expression and cytoprotection assays, in muscle cell lines, adipocytes and others. This is where the mechanisms were proposed and is the strongest part of the record for mechanism and the weakest for physiological relevance.

Does REVIVE LAB UAE provide dosing guidance?

No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.

How fast is delivery in the UAE?

Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.

MOTS-c Pack — in stock, dispatched from Dubai
HPLC-verified, lot certificate on every carton, 24-hour delivery nationwide. Browse the catalogue → All peptides UAE

Related reading

Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.