A single nucleotide change that is silent for the ribosomal RNA function of the gene but alters the peptide encoded in the overlapping frame. Lysine 14 is one of the four basic residues of MOTS-c; glutamine is neutral, so the variant peptide carries one less positive charge. In vitro work in the 2021 study suggested the variant peptide was less active in some assays.
It is one of the clearest cases of a mitochondrial DNA variant affecting a mitochondrial-derived peptide rather than a canonical protein.
The 2015 study compared centenarians with controls in Japan and found the variant more common in the long-lived group, within a haplogroup already associated with longevity. The 2021 study, in Japanese men, found more diabetes among carriers, less so among those who were physically active. The two findings are not contradictory — a variant could associate with both — but neither establishes mechanism.
Both studies were in Japanese populations, where the variant is common enough to study.
That natural variation in the MOTS-c sequence exists, is population-specific, and shows associations with metabolic and ageing phenotypes in observational data. The product in this catalogue is the reference sequence with lysine at 14.
MOTS-c is supplied by REVIVE LAB UAE for laboratory research use only, with identity by mass spectrometry and purity by HPLC for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| MOTS-c Pack | 40 mg | AED 950 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
A single nucleotide change that is silent for the ribosomal RNA function of the gene but alters the peptide encoded in the overlapping frame. Lysine 14 is one of the four basic residues of MOTS-c; glutamine is neutral, so the variant peptide carries one less positive charge. In vitro work in the 2021 study suggested the variant peptide was less active in some assays.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.