MOTS-c in 2015: the paper the whole field rests on

Published 24 October 2026 · REVIVE LAB UAE Research Desk · 5 min read
Changsu Lee, Pinchas Cohen and colleagues described MOTS-c in Cell Metabolism in 2015 as a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene, reporting effects on metabolic pathways including AMPK and on folate-dependent one-carbon metabolism.

The claim that made it interesting

The paper proposed that a short peptide is encoded inside the mitochondrial genome itself and acts beyond the mitochondrion. That is a structural claim about where genetic information sits, and it is the reason the work drew attention well outside metabolism.

MOTS-c was not the first mitochondrial-derived peptide proposed, but it was the one that brought the category into general view.

What was measured

Reported endpoints centred on metabolic regulation: AMPK activation and an effect on folate-dependent one-carbon metabolism, in cell and mouse models. The work is specific about model and method and is worth reading rather than paraphrasing.

These are measurements in defined systems. They are not statements about outcomes in people, and the paper does not make such statements.

What has and has not followed

A body of follow-up work exists on mitochondrial-derived peptides, and the field has grown. It remains young, and much of what circulates commercially about MOTS-c runs far ahead of what has been replicated.

The disciplined summary names the paper, the model and the endpoint, and stops. That sentence is accurate and still interesting, which is the test.

Why that matters when buying material

A supplier can confirm identity and purity for a lot. It cannot confirm what the compound does, and a supplier that offers to is describing marketing rather than evidence.

REVIVE LAB UAE supplies MOTS-c with batch documentation for laboratory research use only, and provides no dosing or protocol guidance of any kind.

What it costs

FormatStrengthPriceAvailability
MOTS-c Pack40 mgAED 950In stock

Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.

Frequently asked

The claim that made it interesting?

The paper proposed that a short peptide is encoded inside the mitochondrial genome itself and acts beyond the mitochondrion. That is a structural claim about where genetic information sits, and it is the reason the work drew attention well outside metabolism.

Does REVIVE LAB UAE provide dosing guidance?

No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.

How fast is delivery in the UAE?

Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.

MOTS-c Pack — in stock, dispatched from Dubai
HPLC-verified, lot certificate on every carton, 24-hour delivery nationwide. Browse the catalogue → All peptides UAE

Related reading

Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.