Four basic residues mean four counterions, and that is part of the mass in the vial

Published 26 October 2026 · REVIVE LAB UAE Research Desk · 5 min read
At the pH of purification, MOTS-c carries about five positive charges — three arginines, one lysine and the amino terminus — partly offset by one glutamate and the carboxyl terminus. In the lyophilised solid each net positive charge is balanced by a counterion from the purification mobile phase. With trifluoroacetate at 113 daltons each, three to four counterions add 15 to 20 per cent to the mass of a 2,174-dalton peptide. Gross mass on the label therefore exceeds peptide mass, and the certificate figure for net peptide content accounts for this and for water.

The charge count

Arginine side chains are always protonated; lysine and the amino terminus are protonated below about pH 9; glutamate and the carboxyl terminus are deprotonated above about pH 4. In the acidic conditions of reversed-phase purification the acidic groups are largely neutral and the peptide carries close to its full positive charge, so the counterion count is at its maximum in the solid.

This is why basic peptides carry more counterion mass than acidic ones.

The mass arithmetic

Four trifluoroacetates add about 452 daltons to 2,174, or 17 per cent. Four acetates at 59 each add 236, or about 10 per cent. Residual water adds a few per cent more. A 40 mg vial of trifluoroacetate salt therefore contains roughly 32 to 34 mg of peptide; the certificate states the measured figure.

The counterion also affects solubility and, for cell work, can itself be biologically active at high concentration, which is why some suppliers exchange to acetate.

On the certificate

Counterion identity and content, water content, and net peptide content as a percentage of gross mass. The 40 mg on the pack is gross mass.

MOTS-c is supplied by REVIVE LAB UAE for laboratory research use only, with identity by mass spectrometry and purity by HPLC for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.

What it costs

FormatStrengthPriceAvailability
MOTS-c Pack40 mgAED 950In stock

Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.

Frequently asked

The charge count?

Arginine side chains are always protonated; lysine and the amino terminus are protonated below about pH 9; glutamate and the carboxyl terminus are deprotonated above about pH 4. In the acidic conditions of reversed-phase purification the acidic groups are largely neutral and the peptide carries close to its full positive charge, so the counterion count is at its maximum in the solid.

Does REVIVE LAB UAE provide dosing guidance?

No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.

How fast is delivery in the UAE?

Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.

MOTS-c Pack — in stock, dispatched from Dubai
HPLC-verified, lot certificate on every carton, 24-hour delivery nationwide. Browse the catalogue → All peptides UAE

Related reading

Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.