The peptide bond is hydrolysed under acid catalysis and under base catalysis by different mechanisms. The rate against pH is therefore a curve with a minimum somewhere in the middle rather than a line.
Where that minimum falls depends on the sequence. For most peptides it is in the mildly acidic to neutral region, which is where diluents tend to sit.
The reaction proceeds through an intermediate whose formation is favoured when the backbone nitrogen is deprotonated, which happens more readily at higher pH. Raising the pH to slow hydrolysis can therefore accelerate deamidation.
That trade-off is the reason stability work reports a profile across a range rather than claiming one optimal value.
Bacteriostatic water is close to neutral and contains 0.9% benzyl alcohol as a preservative. It is a general-purpose diluent, not a stabilising buffer, and it does not address any of the chemistry above.
What does address it is keeping material dry until use, cold afterwards, and out of the light. Those three cover most of what is available to a user without entering formulation work.
The peptide bond is hydrolysed under acid catalysis and under base catalysis by different mechanisms. The rate against pH is therefore a curve with a minimum somewhere in the middle rather than a line.
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