What Is Des(1-3)IGF-1?
Published 2026-07-11 · REVIVE Peptides Research Desk · 2 min read
Short answer: Des(1-3)IGF-1 is a truncated research variant of native IGF-1 in which the first three amino acids at the N-terminal end of the molecule have been removed. Like IGF-1 LR3, it was developed to reduce binding to IGF-binding proteins, but it uses deletion rather than extension to achieve that effect.
The "Des" prefix is standard peptide-chemistry shorthand for "deleted," and "(1-3)" identifies which residues were removed — in this case, the first three of the 70 amino acids that make up native human IGF-1. This is a smaller, more conservative structural change than the modification used to build IGF-1 LR3, which instead adds 13 residues.
Published in-vitro research on Des(1-3)IGF-1 has generally found it retains strong IGF-1 receptor binding while showing reduced affinity for circulating IGF-binding proteins compared to native IGF-1 — the same general research rationale that applies to IGF-1 LR3, achieved through a different structural route. Both variants appear in the growth-factor research literature as tools for studying prolonged IGF-1 receptor activity.
Des(1-3)IGF-1 is an unregulated research chemical, not an approved human or veterinary therapeutic anywhere. It is not part of REVIVE LAB UAE's catalog, is not sold on this site, and this page provides general research information only — no dosing, administration, or therapeutic claim is made.
Not sold by REVIVE LAB UAE. This page is published for research-education purposes only. Des(1-3)IGF-1 is not part of the REVIVE LAB UAE product catalog and no order can be placed for it on this site.
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