What Is the Modification in Tesamorelin?
Short answer: A trans-3-hexenoyl group — a six-carbon unsaturated acyl chain — attached to the amino terminus of the first residue, tyrosine, of the full 44-residue human GHRH sequence. Natural GHRH is cut between its second and third residues by the enzyme DPP-4 within minutes; the hexenoyl group blocks that cut, so tesamorelin persists long enough to act.
Apart from that group the sequence is the natural one, which is why tesamorelin is described as a GHRH analogue rather than a new peptide. Its mass, ≈5136 Da, is the mass of GHRH(1-44) amide plus the hexenoyl group.
The modification is also what distinguishes it chemically from sermorelin, which is the first 29 residues of GHRH without any protecting group.
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Tesamorelin Pack 20 mg — REVIVE LAB UAE
AED 1010 · Lot-specific COA on request · Cash on delivery or USDT (5% off) Order Tesamorelin Pack UAE — Live Stock & Pricing
AED 1010 · Lot-specific COA on request · Cash on delivery or USDT (5% off) Order Tesamorelin Pack UAE — Live Stock & Pricing
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