What Is NAD+ Used For in Research?

NAD+ cycles between an oxidized (NAD+) and reduced (NADH) form, ferrying electrons through cellular energy production in glycolysis and the Krebs cycle. Cellular NAD+ levels decline progressively with age — by age 60, concentrations are typically reduced 50% or more compared to young adults — a decline that has become a central topic in aging and mitochondrial-dysfunction research.

Research on NAD+ focuses heavily on its role activating sirtuins (particularly SIRT1 and SIRT3), longevity-associated enzymes that depend on NAD+ availability, as well as its consumption by PARP enzymes during DNA repair and by CD38, a major NAD+-consuming enzyme that increases with age. The NAD+/NADH ratio itself is studied as a master regulator of cellular metabolism.

NAD+ is not approved as a therapeutic anywhere, including the UAE. REVIVE LAB UAE supplies it exclusively as a research reference material with a lot-specific Certificate of Analysis — not for human or veterinary administration.