Mice placed on a diet high in fat for several weeks become obese and insulin-resistant. Because the obesity arises from diet rather than from a single gene defect, the model is considered more representative of the common human condition than monogenic models such as leptin-deficient mice.
It is the model in which the discovery paper reported retatrutide's effects on intake, weight and energy expenditure, and in which the glucagon component's contribution to expenditure was examined.
The incretin-based agents that reached approval reduced weight in DIO mice before they did so in people, so the model has a record of identifying active compounds in this class. Effect sizes do not translate directly: mice lose a larger fraction of body weight than people do with the same class of agent, for reasons of metabolic rate and thermogenesis.
The model is predictive of direction more reliably than of magnitude.
Glucagon-driven energy expenditure, which the mouse data showed, is harder to measure and likely smaller in humans, whose brown adipose contribution is modest. The human trials did not measure energy expenditure directly, so the contribution of that mechanism in people remains inferred from the mouse.
Retatrutide is supplied by REVIVE LAB UAE as an investigational research material for laboratory use only, with identity by mass spectrometry and purity by HPLC for the batch. It is not approved for any use anywhere, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| Retatrutide Pack | 20 mg | AED 1010 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
Mice placed on a diet high in fat for several weeks become obese and insulin-resistant. Because the obesity arises from diet rather than from a single gene defect, the model is considered more representative of the common human condition than monogenic models such as leptin-deficient mice.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.