Who left the trials, why, and how that shapes the numbers

Published 24 October 2026 · REVIVE LAB UAE Research Desk · 5 min read
Both phase 2 trials reported how many participants discontinued and why. Discontinuation for adverse events rose with dose and was concentrated in the gastrointestinal category. How a trial treats the data of people who left changes the reported result, which is why the papers report more than one analysis and state which the headline uses.

What was reported

Each paper gives, by group, the number randomised, the number completing, and the number discontinuing with reasons: adverse events, withdrawal of consent, loss to follow-up and others. Adverse-event discontinuation was higher in the higher retatrutide groups than in placebo in both trials, driven by gastrointestinal events.

The proportions are in the papers and their supplementary appendices.

Why it changes the result

If people who stop tend to be those with less benefit or more side effects, analysing only completers overstates the effect. If their last measurement is carried forward, it understates it. Modern trials specify in advance how missing data are handled and report the result under more than one assumption.

The NEJM trial reports results under two estimands for this reason, and the difference between them is itself informative.

Reading dropout honestly

A trial with higher dropout in active arms has a tolerability finding embedded in its efficacy result. Both facts belong together: the weight result describes people who stayed on treatment under the stated analysis, and the discontinuation rate describes how many did not.

Retatrutide is supplied by REVIVE LAB UAE as an investigational research material for laboratory use only, with identity by mass spectrometry and purity by HPLC for the batch. It is not approved for any use anywhere, and no dosing, administration or protocol guidance is provided.

What it costs

FormatStrengthPriceAvailability
Retatrutide Pack20 mgAED 1010In stock

Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.

Frequently asked

What was reported?

Each paper gives, by group, the number randomised, the number completing, and the number discontinuing with reasons: adverse events, withdrawal of consent, loss to follow-up and others. Adverse-event discontinuation was higher in the higher retatrutide groups than in placebo in both trials, driven by gastrointestinal events.

Does REVIVE LAB UAE provide dosing guidance?

No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.

How fast is delivery in the UAE?

Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.

Retatrutide Pack — in stock, dispatched from Dubai
HPLC-verified, lot certificate on every carton, 24-hour delivery nationwide. Browse the catalogue → All peptides UAE

Related reading

Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.