What the trials measured, and why each measure was chosen

Published 24 October 2026 · REVIVE LAB UAE Research Desk · 5 min read
The phase 2 trials used percentage change in body weight as the primary endpoint in obesity and change in glycated haemoglobin in type 2 diabetes, with waist circumference, blood pressure, lipids and — in the substudy — MRI liver fat as secondary measures. Each is a validated, measurable proxy chosen for what it reliably reflects, and each has known limits.

Why percentage weight change

Percentage rather than absolute change normalises for starting weight, so that a result is comparable across participants of different sizes. It is objective, cheap to measure, and the regulatory standard for obesity trials. It does not distinguish fat from lean mass, which is why body-composition methods are used alongside it in some trials.

The NEJM trial's primary endpoint was this measure at 24 weeks, with 48 weeks as a key secondary.

Why glycated haemoglobin

Glycated haemoglobin integrates average blood glucose over roughly the preceding three months, because haemoglobin is glycated in proportion to glucose exposure and red cells live about that long. It is stable, standardised and the accepted primary measure for glycaemic trials. It does not capture glucose variability or hypoglycaemia, which are measured separately.

The Lancet trial's primary endpoint was change in this measure at 24 weeks.

The secondary measures

Waist circumference approximates central adiposity. Blood pressure and lipids are cardiovascular risk markers. Liver fat by MRI quantifies hepatic steatosis directly. Each adds information the primary endpoint does not, and each was pre-specified in the trial registration.

Retatrutide is supplied by REVIVE LAB UAE as an investigational research material for laboratory use only, with identity by mass spectrometry and purity by HPLC for the batch. It is not approved for any use anywhere, and no dosing, administration or protocol guidance is provided.

What it costs

FormatStrengthPriceAvailability
Retatrutide Pack20 mgAED 1010In stock

Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.

Frequently asked

Why percentage weight change?

Percentage rather than absolute change normalises for starting weight, so that a result is comparable across participants of different sizes. It is objective, cheap to measure, and the regulatory standard for obesity trials. It does not distinguish fat from lean mass, which is why body-composition methods are used alongside it in some trials.

Does REVIVE LAB UAE provide dosing guidance?

No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.

How fast is delivery in the UAE?

Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.

Retatrutide Pack — in stock, dispatched from Dubai
HPLC-verified, lot certificate on every carton, 24-hour delivery nationwide. Browse the catalogue → All peptides UAE

Related reading

Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.