MRI proton density fat fraction is a quantitative imaging measure of the proportion of liver tissue that is fat. It is non-invasive and reproducible, which is why it has become the standard endpoint for early trials in steatotic liver disease, where biopsy is impractical at scale.
The substudy enrolled participants from the main obesity trial who had a liver fat fraction above a defined threshold at baseline.
Relative reductions in liver fat at 24 and 48 weeks were dose-dependent and large, and most participants in the higher dose groups reached a liver fat fraction below the threshold conventionally taken as normal. Changes in liver fat correlated with changes in body weight and with metabolic markers.
The authors present this as evidence of effect on hepatic fat, and note that histological endpoints — fibrosis in particular — were not assessed and would require separate trials.
Glucagon receptor activity in the liver is one proposed mechanism for the magnitude of hepatic fat reduction, and the authors discuss it; the substudy design cannot isolate it from the effect of weight loss itself.
That is an attribution limit the paper states plainly, and it is worth repeating because it is the kind of distinction secondary summaries drop.
Retatrutide is supplied by REVIVE LAB UAE as an investigational research material for laboratory use only, with identity by mass spectrometry and purity by HPLC for the batch. It is not approved for any use anywhere, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| Retatrutide Pack | 20 mg | AED 1010 | In stock |
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MRI proton density fat fraction is a quantitative imaging measure of the proportion of liver tissue that is fat. It is non-invasive and reproducible, which is why it has become the standard endpoint for early trials in steatotic liver disease, where biopsy is impractical at scale.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.