GLP-1 and GIP are incretins: hormones released from the gut after eating that enhance insulin secretion in a glucose-dependent way. GLP-1 also slows gastric emptying and acts on appetite centres. Glucagon, from the pancreatic alpha cell, raises hepatic glucose output and increases energy expenditure.
Each has a receptor, and each receptor is a target in its own right. Agonists at the GLP-1 receptor alone have been in clinical use for years.
The rationale, set out in the 2022 discovery paper, is that the effects are complementary: incretin activity on glucose and appetite, glucagon activity on energy expenditure and hepatic fat, with the incretin components offsetting glucagon's tendency to raise glucose.
Delivering that through one molecule rather than three avoids three pharmacokinetic profiles and three sets of interactions. Whether the combination performs as the rationale predicts is what the trials measured.
That three receptors are engaged says nothing about how strongly each is engaged. Retatrutide's potencies differ across the three, deliberately, and the balance is a property of this molecule rather than of triple agonists as a class.
Two triple agonists with different receptor ratios would be different compounds with different effects. The label describes a category, not a molecule.
Retatrutide is supplied by REVIVE LAB UAE as an investigational research material for laboratory use only, with identity by mass spectrometry and purity by HPLC for the batch. It is not approved for any use anywhere, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| Retatrutide Pack | 20 mg | AED 1010 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
GLP-1 and GIP are incretins: hormones released from the gut after eating that enhance insulin secretion in a glucose-dependent way. GLP-1 also slows gastric emptying and acts on appetite centres. Glucagon, from the pancreatic alpha cell, raises hepatic glucose output and increases energy expenditure.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.