The asparagine side chain amide attacks the backbone nitrogen of the following residue, forming a five-membered succinimide ring that hydrolyses to a mixture of aspartate and isoaspartate, the latter with the backbone rerouted through the side chain. For GHRH the Asn-Ser sequence at positions 8 and 9 is the vulnerable site. The reaction adds one dalton and a negative charge, and the isoaspartyl product separates on reversed-phase and ion-exchange chromatography.
Deamidated GHRH has been reported to retain a fraction of the activity of the intact peptide.
Methionine 27 lies in the carboxyl-terminal region, outside the minimal 1-29 active core but near its end. Oxidation to the sulfoxide adds sixteen daltons and is driven by dissolved oxygen, peroxide traces and light. The sulfoxide elutes earlier on reversed phase. The hexenoyl group of tesamorelin is a six-carbon alkene and is itself a potential oxidation site, though it is not reported as a major degradant.
Protect-from-light storage addresses the photochemical route.
Both degradants appear within related substances under the stated chromatographic method. A fresh lot shows little of either; a solution left in air and light shows more. The batch certificate for the pack reports what was found.
Tesamorelin is supplied by REVIVE LAB UAE for laboratory research use only, with identity by mass spectrometry and purity by HPLC for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| Tesamorelin Pack | 20 mg | AED 1010 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
The asparagine side chain amide attacks the backbone nitrogen of the following residue, forming a five-membered succinimide ring that hydrolyses to a mixture of aspartate and isoaspartate, the latter with the backbone rerouted through the side chain. For GHRH the Asn-Ser sequence at positions 8 and 9 is the vulnerable site. The reaction adds one dalton and a negative charge, and the isoaspartyl product separates on reversed-phase and ion-exchange chromatography.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.