Somatotrophs are present at birth but fail to proliferate, so the pituitary stays small; growth hormone is nearly undetectable; IGF-1 is low; growth falls behind after weaning and adult size is about half of normal. Unlike mice lacking the pituitary transcription factors, other pituitary cell types are intact. The mice are long-lived relative to wild type, as other growth-hormone-deficient mice are.
Giving growth hormone restores growth, placing the defect upstream of the pituitary response.
That GHRH is necessary and not redundant — ghrelin and other secretagogues do not compensate for its absence; that the developmental expansion of somatotrophs depends on it; and that the receptor and ligand knockouts match, so the receptor has no other important ligand. For a releasing-hormone analogue the models say what it needs: an intact receptor and somatotrophs, and in that setting it supplies the signal the ligand knockout lacks.
Human GHRH deficiency without receptor mutation is rare and poorly characterised, so the mouse is the main model.
Because the knockout is the genetic proof of the pharmacology on which tesamorelin rests. It describes mouse genetics and no use of the pack.
Tesamorelin is supplied by REVIVE LAB UAE for laboratory research use only, with identity by mass spectrometry and purity by HPLC for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| Tesamorelin Pack | 20 mg | AED 1010 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
Somatotrophs are present at birth but fail to proliferate, so the pituitary stays small; growth hormone is nearly undetectable; IGF-1 is low; growth falls behind after weaning and adult size is about half of normal. Unlike mice lacking the pituitary transcription factors, other pituitary cell types are intact. The mice are long-lived relative to wild type, as other growth-hormone-deficient mice are.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.