Ligand binding to the large extracellular amino-terminal domain and the transmembrane core activates Gs, raises cyclic AMP, and through protein kinase A and the transcription factor CREB stimulates both release of stored growth hormone and transcription of the growth hormone gene, as well as proliferation of somatotrophs during development. Expression of the receptor is itself induced by the pituitary transcription factor Pit-1 and by glucocorticoids, and suppressed by growth hormone and IGF-1 feedback.
It is the receptor that somatostatin, acting through its own receptors, opposes.
The little mouse has a missense change that prevents GHRH from binding. Its somatotrophs never expand, so the pituitary is small and growth hormone very low, and growth hormone itself restores growth, which places the defect upstream. Human families with receptor mutations show severe proportionate short stature with low growth hormone that does not respond to GHRH but does respond to growth hormone — the human little mouse. These cases are the genetic proof that the receptor is necessary for the axis.
They are also the one population in which a GHRH analogue cannot work by construction.
Because the receptor is what tesamorelin acts on and the genetics define what it does. It describes receptor biology and no use of the pack.
Tesamorelin is supplied by REVIVE LAB UAE for laboratory research use only, with identity by mass spectrometry and purity by HPLC for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| Tesamorelin Pack | 20 mg | AED 1010 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
Ligand binding to the large extracellular amino-terminal domain and the transmembrane core activates Gs, raises cyclic AMP, and through protein kinase A and the transcription factor CREB stimulates both release of stored growth hormone and transcription of the growth hormone gene, as well as proliferation of somatotrophs during development. Expression of the receptor is itself induced by the pituitary transcription factor Pit-1 and by glucocorticoids, and suppressed by growth hormone and IGF-1 feedback.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.