Most cytoplasmic proteins in mammals are acetylated at the amino terminus by enzymes acting as the chain emerges from the ribosome. For thymosin beta-4 the acetylated serine is the natural state, and the acetylated form is what the extracellular literature used when it used the full protein. The modification removes the positive charge of the terminal amine, which affects how the protein binds actin and how it is cleaved to the tetrapeptide metabolite.
Unacetylated recombinant protein has been studied and behaves somewhat differently.
A fragment made by solid-phase synthesis has a free amino terminus by default. Coupling acetic anhydride or acetic acid to the terminal amine as the final step gives an acetylated fragment, which resists aminopeptidases and may better mimic the natural protein in that region. Whether a given lot is acetylated is a matter of its synthesis and is read from the calculated mass on the certificate: 42 daltons more than the unacetylated sequence.
The page on which mass the certificate should show covers the same question from the other direction.
Acetyl on the terminus is covalent and part of the molecule. Acetate as counterion is an ion paired with the lysines in the solid and separable from the peptide. A product named as an acetate salt says nothing about terminal acetylation, and a reader should not infer one from the other.
The BPC-157 + TB500 blend is supplied by REVIVE LAB UAE for laboratory research use only, with identity by mass spectrometry and purity by HPLC for each component of the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| BPC-157 + TB500 Pack | 5 mg + 5 mg | AED 510 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
Most cytoplasmic proteins in mammals are acetylated at the amino terminus by enzymes acting as the chain emerges from the ribosome. For thymosin beta-4 the acetylated serine is the natural state, and the acetylated form is what the extracellular literature used when it used the full protein. The modification removes the positive charge of the terminal amine, which affects how the protein binds actin and how it is cleaved to the tetrapeptide metabolite.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.