Native IGF-1 in circulation is largely bound to IGF-binding proteins, which control how much is free to reach receptors. In culture, binding proteins secreted by the cells themselves do the same thing — they absorb added IGF-1 and make the delivered amount hard to know.
That is a measurement problem: the concentration added and the concentration available are not the same number.
Substituting arginine at position 3 reduces affinity for the binding proteins. The N-terminal extension adds to the same effect. The result is an analogue that stays comparatively free in the presence of binding proteins.
That is why LR3 appears so often in cell culture work: it makes the exposure more predictable than native IGF-1 in the same dish.
It is not IGF-1. It is an analogue with deliberately altered binding behaviour, so results obtained with it describe the analogue. Where binding-protein interaction is part of the biology under study, the modification removes the thing being studied.
Reporting a result as "IGF-1 did X" when the material was LR3 is an attribution the experiment does not support.
IGF-1 LR3, 1 mg, boxed with a 3 mL bacteriostatic water vial, with a lot-specific Certificate of Analysis.
Research use only. No dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| IGF-1 LR3 Pack | 1 mg | AED 650 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
Native IGF-1 in circulation is largely bound to IGF-binding proteins, which control how much is free to reach receptors. In culture, binding proteins secreted by the cells themselves do the same thing — they absorb added IGF-1 and make the delivered amount hard to know.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.