Rats without a pituitary do not grow. Injecting the hormone into one growth plate produced measurable widening of that plate and lengthening of that bone, with the contralateral leg as the control. The amount used was too small to raise circulating IGF-1. The conclusion was that the hormone itself acts on the cartilage, which the prevailing hypothesis had denied.
Later work with local IGF-1 antibodies showed the local effect still needed IGF-1, made in the plate itself.
In the growth plate, resting-zone chondrocytes are the stem population. Growth hormone acts on them directly to start differentiation and to switch on local IGF-1 expression; the IGF-1 then acts on the newly committed cells to make them divide. Two effectors, one upstream and one downstream, in the same tissue. The model was built on fat cell precursors as well as cartilage.
It is the framework that the liver-specific IGF-1 knockout of 1999 later confirmed from the other direction.
Because the growth plate is where the hormone in this pack does the thing it is named for, and the mechanism was worked out in these experiments. This is physiology, stated as history.
Somatropin is supplied by REVIVE LAB UAE for laboratory research use only, with identity and purity documented for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| HGH Somatropin Pack | 24 mg (72 IU) | AED 850 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
Rats without a pituitary do not grow. Injecting the hormone into one growth plate produced measurable widening of that plate and lengthening of that bone, with the contralateral leg as the control. The amount used was too small to raise circulating IGF-1. The conclusion was that the hormone itself acts on the cartilage, which the prevailing hypothesis had denied.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.