Rat cartilage in culture takes up sulfate as it makes matrix. Growth hormone added directly did not increase uptake; serum from animals given growth hormone did. The simplest explanation was a circulating mediator made in response to the hormone. Published in the Journal of Laboratory and Clinical Medicine in 1957.
The factor was purified over the following two decades and shown to be identical to IGF-1.
Liver makes most of the IGF-1 in blood. Deleting the gene there, using a liver-specific recombinase, removed the endocrine supply while leaving local production elsewhere intact. The mice reached normal size, which was not what a strictly endocrine hypothesis predicted. Both papers appeared in the Proceedings of the National Academy of Sciences.
Later work showed effects on other systems in those mice, so circulating IGF-1 is not without function; it is not required for linear growth.
Growth hormone acts directly on some tissues, induces IGF-1 locally in many, and induces liver IGF-1 that acts as a hormone. The three are not alternatives. The history is a clear example of a correct observation generating a hypothesis that was then narrowed by a sharper experiment.
Somatropin is supplied by REVIVE LAB UAE for laboratory research use only, with identity and purity documented for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| HGH Somatropin Pack | 24 mg (72 IU) | AED 850 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
Rat cartilage in culture takes up sulfate as it makes matrix. Growth hormone added directly did not increase uptake; serum from animals given growth hormone did. The simplest explanation was a circulating mediator made in response to the hormone. Published in the Journal of Laboratory and Clinical Medicine in 1957.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.