JAK2 associates with the membrane-proximal region of each receptor chain. When the hormone brings the two chains into the active arrangement, the two kinases phosphorylate each other and then tyrosines on the receptor tails. This was among the first demonstrations of how a cytokine receptor without its own catalytic domain signals.
The same mechanism applies across the class I cytokine receptor family.
Phosphorylated receptor tyrosines dock STAT5, which JAK2 phosphorylates in turn. STAT5 dimerises, enters the nucleus and binds target promoters. The IGF-1 gene is one of them, which connects receptor activation to the somatomedin story.
Other branches — MAP kinase, PI3 kinase — are also engaged, but STAT5b accounts for the growth phenotype.
Individuals with inactivating STAT5b mutations have severe growth failure with normal or high growth hormone and low IGF-1, demonstrating in humans that this branch carries the growth signal. The pathway is therefore established both biochemically and genetically.
Somatropin is supplied by REVIVE LAB UAE for laboratory research use only, with identity and purity documented for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| HGH Somatropin Pack | 24 mg (72 IU) | AED 850 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
JAK2 associates with the membrane-proximal region of each receptor chain. When the hormone brings the two chains into the active arrangement, the two kinases phosphorylate each other and then tyrosines on the receptor tails. This was among the first demonstrations of how a cytokine receptor without its own catalytic domain signals.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.