Replacing residues one at a time with alanine and measuring binding identified a patch on helix 4 and the first crossover loop whose mutation cost most of the affinity. This was the first systematic functional map of a hormone-receptor interface and established alanine scanning as a method.
It was done before the structure was known.
The crystal structure showed a second receptor contacting a different face of the hormone, mainly helices 1 and 3, through a smaller interface. The two receptor molecules also contact each other. Binding is sequential: site 1 first, then site 2 recruits the second receptor.
Later work indicated the receptor exists as a preformed dimer that the hormone rearranges rather than assembles, but the two-site binding stands.
A single substitution at site 2, glycine 120 to arginine, gives a molecule that occupies one receptor and cannot engage the second. Pegylated, it is pegvisomant, an approved antagonist. The mechanism therefore produced both the picture of activation and a way to block it.
Somatropin is supplied by REVIVE LAB UAE for laboratory research use only, with identity and purity documented for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| HGH Somatropin Pack | 24 mg (72 IU) | AED 850 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
Replacing residues one at a time with alanine and measuring binding identified a patch on helix 4 and the first crossover loop whose mutation cost most of the affinity. This was the first systematic functional map of a hormone-receptor interface and established alanine scanning as a method.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.