Binding of human growth hormone to the extracellular domain of the prolactin receptor was found to depend on zinc at physiological concentration and to be abolished by chelation. Mutagenesis located the zinc ligands: histidine 18, histidine 21 and glutamate 174 on the hormone, and a histidine on the receptor. Binding to the growth hormone receptor needed no zinc. A single metal ion therefore switches one hormone between two receptors.
It was an early example of metal-dependent protein-protein recognition in a hormone system.
In vivo, human growth hormone has prolactin-like effects on the breast and reproductive tissues that animal hormones lack, and these appear among its known effects at high levels. In vitro, the widely used Nb2 cell assay responds through the prolactin receptor, so it measures lactogenic potency; assays using cells engineered with the growth hormone receptor measure somatogenic potency. The two usually agree for intact hormone and can diverge for variants.
Placental lactogen and prolactin, the other members of the family, bind the prolactin receptor without zinc.
Because it is part of what is established about the receptor pharmacology of the molecule in the pack, and because a certificate potency figure depends on which receptor the assay used.
Somatropin is supplied by REVIVE LAB UAE for laboratory research use only, with identity and purity documented for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| HGH Somatropin Pack | 24 mg (72 IU) | AED 850 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
Binding of human growth hormone to the extracellular domain of the prolactin receptor was found to depend on zinc at physiological concentration and to be abolished by chelation. Mutagenesis located the zinc ligands: histidine 18, histidine 21 and glutamate 174 on the hormone, and a histidine on the receptor. Binding to the growth hormone receptor needed no zinc. A single metal ion therefore switches one hormone between two receptors.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.