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The decline of growth hormone secretion with age, the term coined for it, and the argument about what it means

Published 26 October 2026 · REVIVE LAB UAE Research Desk · 5 min read
Twenty-four-hour growth hormone secretion declines progressively from the third decade, by something like fourteen per cent per decade in cross-sectional studies, through smaller pulses rather than fewer, and IGF-1 declines in parallel so that levels in the seventh decade are about half those of young adults. The term somatopause was introduced in the 1990s to frame this as an endocrine deficiency of ageing comparable to menopause. The analogy has been disputed: the decline is gradual rather than abrupt, the axis remains responsive, and the trials that treated it, summarised in the 2007 review, found little benefit and measurable harm.

What declines

Pulse amplitude, especially of the nocturnal pulse, in parallel with the loss of slow-wave sleep. Releasing-hormone output falls and somatostatin tone rises. Body fat, which increases with age, suppresses secretion further. IGF-1 falls, and the IGF-1 response to a given amount of hormone is somewhat reduced. These changes are universal and the reference ranges for IGF-1 are age-adjusted for them.

The decline is one of the most reproducible endocrine changes of ageing.

The argument

One view holds that the decline causes some of the composition changes of ageing and should be corrected. The other holds that it is adaptive or neutral, points to the longevity of animals and people with low signalling through this axis, and to the trial evidence of harm without benefit. The second view has prevailed in guidelines, which do not recognise age-related decline as an indication.

The term remains in use descriptively.

Why it is here

Because the decline is established and the interpretation is not, and a reader should know both. This page describes physiology and a debate; it describes no use of the pack.

Somatropin is supplied by REVIVE LAB UAE for laboratory research use only, with identity and purity documented for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.

What it costs

FormatStrengthPriceAvailability
HGH Somatropin Pack24 mg (72 IU)AED 850In stock

Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.

Frequently asked

What declines?

Pulse amplitude, especially of the nocturnal pulse, in parallel with the loss of slow-wave sleep. Releasing-hormone output falls and somatostatin tone rises. Body fat, which increases with age, suppresses secretion further. IGF-1 falls, and the IGF-1 response to a given amount of hormone is somewhat reduced. These changes are universal and the reference ranges for IGF-1 are age-adjusted for them.

Does REVIVE LAB UAE provide dosing guidance?

No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.

How fast is delivery in the UAE?

Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.

HGH Somatropin Pack — in stock, dispatched from Dubai
HPLC-verified, lot certificate on every carton, 24-hour delivery nationwide. Browse the catalogue → All peptides UAE

Related reading

→ HGH Somatropin Pack — 24 mg (72 IU) → Rudman 1990 and what came after → IGF-1 signalling and longevity

Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.