Sequenced by Rinderknecht and Humbel in 1978 alongside IGF-1. In rodents IGF-2 expression falls sharply after birth; in humans it remains high in adult serum, at several times the IGF-1 concentration, carried in the same ternary complex. Its physiological role in adult humans is less defined than that of IGF-1.
Loss of imprinting at IGF2 is a feature of several tumours and of the overgrowth condition Beckwith-Wiedemann syndrome.
The IGF-1 receptor binds both factors and signals. The IGF-2 receptor is the cation-independent mannose-6-phosphate receptor, a large single-chain protein that binds IGF-2 and routes it to lysosomes; it has no kinase and functions as a clearance receptor. IGF-2 also activates the insulin receptor isoform expressed in fetal and tumour tissue.
IGF-1 binds the IGF-2 receptor negligibly.
The growth hormone axis, the knockout genetics and the culture-supplement literature all centre on IGF-1. An analogue intended to deliver IGF-1 receptor agonism in culture was naturally built on it. There is no equivalent engineered IGF-2 in common use.
IGF-1 LR3 is supplied by REVIVE LAB UAE for laboratory research use only, with identity and purity documented for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| IGF-1 LR3 Pack | 1 mg | AED 650 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
Sequenced by Rinderknecht and Humbel in 1978 alongside IGF-1. In rodents IGF-2 expression falls sharply after birth; in humans it remains high in adult serum, at several times the IGF-1 concentration, carried in the same ternary complex. Its physiological role in adult humans is less defined than that of IGF-1.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.