The barrier endothelium expresses IGF-1 receptors and transports the hormone by transcytosis, with the choroid plexus a second route. Neurons and astrocytes make IGF-1 locally, especially during development, when the IGF1 gene deletion case showed its necessity for brain growth and hearing. In the adult brain it is studied for neuroprotection, synaptic plasticity and the regulation of amyloid clearance.
The brain is one of the tissues where local and circulating IGF-1 both contribute.
Running rodents took up more circulating IGF-1 into the brain, and the hormone accumulated in neurons activated by the exercise. Antibodies that neutralised circulating IGF-1 prevented the exercise-induced birth of new neurons in the hippocampus and the protective effect of exercise against brain injury. These studies made circulating IGF-1 a candidate mediator of the cognitive effects of exercise.
Later work added other mediators, so IGF-1 is one of several.
Cohort studies relating IGF-1 to cognition or dementia risk are inconsistent in direction. The Laron cohort, with lifelong low IGF-1, has not shown cognitive deficit. No interventional data exist. This page describes rodent mechanism and human association, and describes no use of the pack.
IGF-1 LR3 is supplied by REVIVE LAB UAE for laboratory research use only, with identity and purity documented for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| IGF-1 LR3 Pack | 1 mg | AED 650 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
The barrier endothelium expresses IGF-1 receptors and transports the hormone by transcytosis, with the choroid plexus a second route. Neurons and astrocytes make IGF-1 locally, especially during development, when the IGF1 gene deletion case showed its necessity for brain growth and hearing. In the adult brain it is studied for neuroprotection, synaptic plasticity and the regulation of amyloid clearance.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.