The deletion removed exons 4 and 5, producing no functional protein. Growth hormone was high because the feedback through IGF-1 was absent. Treatment with recombinant IGF-1 improved growth, confirming the defect was the ligand and not the receptor.
It remains one of very few reported human IGF1 null individuals.
Abuzzahab and colleagues reported in 2003 compound heterozygous and heterozygous IGF1R mutations in children with intrauterine growth retardation and short stature, with high rather than low IGF-1. These are milder because one functional allele remains; complete loss is presumed lethal, as in the mouse.
Together the ligand and receptor cases map the human pathway at both ends.
They move the necessity of IGF-1 from mouse genetics to human genetics. They also show the system has roles in the nervous system and metabolism beyond stature. This is physiology and genetics, not a description of any use of the material.
IGF-1 LR3 is supplied by REVIVE LAB UAE for laboratory research use only, with identity and purity documented for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| IGF-1 LR3 Pack | 1 mg | AED 650 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
The deletion removed exons 4 and 5, producing no functional protein. Growth hormone was high because the feedback through IGF-1 was absent. Treatment with recombinant IGF-1 improved growth, confirming the defect was the ligand and not the receptor.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.