Igf1 null: sixty per cent birth weight, most die within hours, survivors remain about thirty per cent of adult size. Igf2 null: sixty per cent birth weight, normal postnatal growth rate, viable — IGF-2 being mainly a fetal factor in the mouse. Igf1r null: forty-five per cent, uniformly lethal at birth, with underdeveloped muscle and lung.
Each phenotype is proportionate dwarfism, not malformation.
Igf1 and Igf1r together gave the same forty-five per cent as Igf1r alone, so IGF-1 has no receptor-independent action. Igf2 and Igf1r together gave thirty per cent, less than either, so IGF-2 must act partly through something other than the IGF-1 receptor — later shown to be the insulin receptor. Such epistasis experiments defined the wiring of the system.
Growth hormone receptor knockouts, made later, are less severe at birth and fall behind postnatally, which placed growth hormone upstream and mainly postnatal.
Anything about adding the factor to a normal animal. They show what is missing when the gene is missing. Human gene deletions, reported three years later, gave the same answer.
IGF-1 LR3 is supplied by REVIVE LAB UAE for laboratory research use only, with identity and purity documented for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| IGF-1 LR3 Pack | 1 mg | AED 650 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
Igf1 null: sixty per cent birth weight, most die within hours, survivors remain about thirty per cent of adult size. Igf2 null: sixty per cent birth weight, normal postnatal growth rate, viable — IGF-2 being mainly a fetal factor in the mouse. Igf1r null: forty-five per cent, uniformly lethal at birth, with underdeveloped muscle and lung.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.