Monoclonal antibodies recognise a few residues. One directed at the B domain near the amino terminus may be blocked by the extension; one directed at the C or D domain binds the analogue as well as the native protein. Sandwich assays need two antibodies to bind simultaneously, so they are more sensitive to any change. Calibration is against native IGF-1, so even an antibody that binds the analogue may report it at a different apparent concentration.
The same problem affects measurement of every engineered protein with its parent assay.
For a laboratory wanting the concentration of LR3 in a solution, chromatography against an LR3 standard or absorbance-based methods are the appropriate tools, not an IGF-1 kit. For a clinical IGF-1 result in anyone exposed to the analogue, the number is uninterpretable: it may include analogue, exclude it, or be suppressed by the feedback the analogue causes. For anti-doping, the variability is why confirmation is by mass spectrometry.
The culture-reagent manufacturers quantify by chromatography and bioassay for the same reason.
Because it is a practical analytical fact about the molecule that follows from its design, and because the question is often asked. It describes no use of the pack.
IGF-1 LR3 is supplied by REVIVE LAB UAE for laboratory research use only, with identity and purity documented for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| IGF-1 LR3 Pack | 1 mg | AED 650 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
Monoclonal antibodies recognise a few residues. One directed at the B domain near the amino terminus may be blocked by the extension; one directed at the C or D domain binds the analogue as well as the native protein. Sandwich assays need two antibodies to bind simultaneously, so they are more sensitive to any change. Calibration is against native IGF-1, so even an antibody that binds the analogue may report it at a different apparent concentration.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.