The one test that reads the first residues directly

Published 26 October 2026 · REVIVE LAB UAE Research Desk · 5 min read
Edman degradation chemically cleaves the amino-terminal residue of a protein, identifies it by chromatography, and repeats, reading the sequence from the amino end for ten to thirty cycles. Applied to IGF-1 LR3 it reads the residues of the extension first, which native IGF-1 does not have, and then continues into the IGF-1 sequence where the arginine at position 3 of IGF-1 numbering appears in place of glutamate. It is the direct confirmation that the extension is present and intact, and it also detects truncation or a retained initiator methionine.

The method

Phenyl isothiocyanate reacts with the free amino terminus; acid cleaves the derivatised residue; it is identified against standards; the shortened protein goes round again. Each cycle has a small inefficiency, so the signal fades after a few dozen residues, which is enough to read the extension and the start of the core.

Mass spectrometry has largely replaced it for whole-sequence work, but it remains definitive for the amino terminus.

What it shows for LR3

That the chain starts where the design says it should, with the extension; that the extension is complete and not clipped; and that the junction with the IGF-1 sequence is correct. A product that read Gly-Pro-Glu from the first cycle would be native IGF-1, not the analogue. A blocked terminus, which stops the reaction, would indicate a modification.

The method cannot see the rest of the molecule and is used alongside mass and mapping.

On a certificate

Reported as the first several residues matching the expected sequence. Where it is run, it is the cleanest confirmation that the product is the analogue and not the parent.

IGF-1 LR3 is supplied by REVIVE LAB UAE for laboratory research use only, with identity and purity documented for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.

What it costs

FormatStrengthPriceAvailability
IGF-1 LR3 Pack1 mgAED 650In stock

Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.

Frequently asked

The method?

Phenyl isothiocyanate reacts with the free amino terminus; acid cleaves the derivatised residue; it is identified against standards; the shortened protein goes round again. Each cycle has a small inefficiency, so the signal fades after a few dozen residues, which is enough to read the extension and the start of the core.

Does REVIVE LAB UAE provide dosing guidance?

No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.

How fast is delivery in the UAE?

Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.

IGF-1 LR3 Pack — in stock, dispatched from Dubai
HPLC-verified, lot certificate on every carton, 24-hour delivery nationwide. Browse the catalogue → All peptides UAE

Related reading

Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.