The insulin and IGF-1 receptors are close relatives and each binds the other ligand weakly. At high enough concentration insulin occupies IGF-1 receptors and signals through them, and also signals through its own receptor, which many cell lines express. The effect was real but inefficient, and the concentrations needed were far from anything physiological.
Insulin also degrades in culture medium over days, requiring replenishment.
Direct, high-affinity agonism of the intended receptor; no loss to binding proteins; stability in medium; and a defined, recombinant, animal-origin-free source. The amount needed fell by two to three orders of magnitude. For large-scale production of therapeutic proteins, where media cost and definition matter, that was decisive.
Some media retain insulin for its own receptor effects and add the analogue for the IGF-1 receptor.
This page describes a substitution made in the formulation of commercial culture media and the receptor pharmacology behind it. It describes no use of the pack.
IGF-1 LR3 is supplied by REVIVE LAB UAE for laboratory research use only, with identity and purity documented for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| IGF-1 LR3 Pack | 1 mg | AED 650 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
The insulin and IGF-1 receptors are close relatives and each binds the other ligand weakly. At high enough concentration insulin occupies IGF-1 receptors and signals through them, and also signals through its own receptor, which many cell lines express. The effect was real but inefficient, and the concentrations needed were far from anything physiological.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.