IGF-1 LR3: an analogue designed to evade its own binding proteins

Published 9 October 2026 · REVIVE LAB UAE Research Desk · 5 min read
Long R3 IGF-1 is an analogue of insulin-like growth factor 1 carrying an N-terminal extension and a substitution at position 3. This catalogue lists it as an 83-amino-acid analogue of about 9111 daltons. Both modifications reduce binding to the IGF-binding proteins that normally sequester native IGF-1.

What the binding proteins do

Native IGF-1 circulates largely bound to a family of IGF-binding proteins rather than free. They regulate how much is available to act at any moment, extending its half-life while limiting immediate availability.

In cell culture that regulation is an obstacle. Binding proteins present in the medium, or secreted by the cells themselves, sequester added IGF-1 and make the effective concentration something other than what was added.

What the two changes are for

The arginine substitution at position 3 reduces affinity for the binding proteins. The N-terminal extension — the "Long" in the name — adds to that effect.

The result is an analogue less readily sequestered, which makes the concentration applied in a culture experiment closer to the concentration acting. That is the reason the analogue exists: it is a research tool designed around a specific experimental problem.

How it is supplied

As a boxed pack holding the 1 mg vial together with a 3 mL bacteriostatic water vial, under one batch record with the lot certificate and a verification code.

Supplied for laboratory research use only. REVIVE LAB UAE provides no dosing, administration or protocol guidance of any kind.

What it costs

FormatStrengthPriceAvailability
IGF-1 LR3 Pack1 mgAED 900In stock

Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.

Frequently asked

What the binding proteins do?

Native IGF-1 circulates largely bound to a family of IGF-binding proteins rather than free. They regulate how much is available to act at any moment, extending its half-life while limiting immediate availability.

Does REVIVE LAB UAE provide dosing guidance?

No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.

How fast is delivery in the UAE?

Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.

IGF-1 LR3 Pack — in stock, dispatched from Dubai
HPLC-verified, lot certificate on every carton, 24-hour delivery nationwide. Browse the catalogue → All peptides UAE

Related reading

Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.