Preclinical work showed IGF-1 receptor signalling protected tumour cells from chemotherapy, and early trials in Ewing sarcoma showed responses in a minority. Phase 3 trials in common cancers followed, adding the antibody to standard chemotherapy. The lung cancer trial of figitumumab enrolled hundreds of patients before an interim analysis showed more deaths with the antibody.
By 2014 most programmes had been discontinued.
The insulin receptor, especially its A isoform, is expressed on tumours and signals through the same pathway; blocking the IGF-1 receptor alone leaves it open, and the rise in insulin that follows from the glucose effects feeds it. Hybrid receptors complicate the picture further. No biomarker identified the patients who would benefit. The biology that made the target attractive also made it redundant.
The failures are a standard case study in why pathway redundancy defeats single-target drugs.
Because it is the largest body of human data on blocking the receptor that IGF-1 LR3 activates, and because it describes what that receptor does in tumours. It describes no use of the pack.
IGF-1 LR3 is supplied by REVIVE LAB UAE for laboratory research use only, with identity and purity documented for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| IGF-1 LR3 Pack | 1 mg | AED 650 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
Preclinical work showed IGF-1 receptor signalling protected tumour cells from chemotherapy, and early trials in Ewing sarcoma showed responses in a minority. Phase 3 trials in common cancers followed, adding the antibody to standard chemotherapy. The lung cancer trial of figitumumab enrolled hundreds of patients before an interim analysis showed more deaths with the antibody.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.