A single precursor is cleaved into alpha and beta; two alpha-beta halves are joined by disulfides into the mature receptor. Ligand binds across the two alpha subunits, and the conformational change activates the two kinase domains, which phosphorylate each other and then docking proteins, chiefly the insulin receptor substrates.
Unlike most receptor tyrosine kinases, it is a covalent dimer before ligand arrives.
The IGF-1 receptor binds IGF-1 with about a hundredfold higher affinity than insulin, and the insulin receptor the reverse. IGF-2 binds both. The structural basis lies in the ligand-binding alpha subunits, which differ more than the kinase domains do. The downstream machinery is largely shared, which is the basis of the crosstalk discussed elsewhere on this site.
The receptor is expressed on nearly every cell type, which is why IGF-1 acts so broadly.
IGF-1 LR3 binds this receptor with affinity close to that of native IGF-1 — the modifications were selected to spare receptor binding while reducing binding-protein affinity. The receptor is therefore the same target; what differs is how much free ligand reaches it.
IGF-1 LR3 is supplied by REVIVE LAB UAE for laboratory research use only, with identity and purity documented for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| IGF-1 LR3 Pack | 1 mg | AED 650 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
A single precursor is cleaved into alpha and beta; two alpha-beta halves are joined by disulfides into the mature receptor. Ligand binds across the two alpha subunits, and the conformational change activates the two kinase domains, which phosphorylate each other and then docking proteins, chiefly the insulin receptor substrates.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.