IGF-1 binds IGFBP-3 with high affinity to form a binary complex; the acid-labile subunit then binds the binary complex, not free IGFBP-3, to close the ternary complex. The subunit is named for falling apart at acid pH, which is how it was discovered. All three are induced by growth hormone, so the whole reservoir rises and falls together.
IGFBP-5 can substitute for IGFBP-3 in a minor ternary pool.
It is a reservoir. It keeps IGF-1 in the circulation, prevents it from acting on the insulin receptor at high concentration, and releases it by proteolysis of the binding protein where needed. Total serum IGF-1, the quantity measured clinically, is mostly complex-bound and reflects growth hormone status over days.
Free IGF-1 is a small fraction and much harder to measure.
An analogue that cannot be bound is not stored or protected in this way. In cell culture that means more free ligand; in an animal it means a short half-life and no reservoir. Both are consequences of the same property, and both are reasons LR3 is a research reagent rather than a therapeutic.
IGF-1 LR3 is supplied by REVIVE LAB UAE for laboratory research use only, with identity and purity documented for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| IGF-1 LR3 Pack | 1 mg | AED 650 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
IGF-1 binds IGFBP-3 with high affinity to form a binary complex; the acid-labile subunit then binds the binary complex, not free IGFBP-3, to close the ternary complex. The subunit is named for falling apart at acid pH, which is how it was discovered. All three are induced by growth hormone, so the whole reservoir rises and falls together.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.