IGFBP-3 in pregnancy serum appears on western blots as fragments rather than the intact protein, and the fragments bind IGF-1 weakly. Total IGF-1 is little changed but a larger fraction is free. The protease, later identified as a pregnancy-associated plasma protein, is one of several; the physiological purpose is presumed to be increased IGF availability for fetal and maternal growth.
It was the first evidence that the binding proteins are regulated by cleavage as well as by synthesis.
Prostate-specific antigen is the enzyme measured in blood for prostate cancer screening. Its substrate in semen is a gel-forming protein; in prostate tissue it also cleaves IGFBP-3. The finding linked the IGF system to the prostate at a time when the epidemiological association between IGF-1 and prostate cancer was emerging, and it suggested a route by which tumour tissue could liberate growth factor locally.
Whether this matters in vivo remains studied; the biochemistry is established.
Because it completes the picture of the binding proteins as a regulated reservoir rather than a fixed sink, and because the analogue in the pack is a molecule designed to need no such release.
IGF-1 LR3 is supplied by REVIVE LAB UAE for laboratory research use only, with identity and purity documented for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| IGF-1 LR3 Pack | 1 mg | AED 650 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
IGFBP-3 in pregnancy serum appears on western blots as fragments rather than the intact protein, and the fragments bind IGF-1 weakly. Total IGF-1 is little changed but a larger fraction is free. The protease, later identified as a pregnancy-associated plasma protein, is one of several; the physiological purpose is presumed to be increased IGF availability for fetal and maternal growth.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.