Two of the bonds, 18-61 and 47-52 in IGF-1 numbering, correspond to the interchain and intrachain bonds of insulin. The third, 6-48, links the B domain to the A domain. Together they hold a compact fold of three short helices. The protein is small enough that the disulfides contribute much of its stability.
Reduction unfolds it completely.
Oxidising six cysteines can give fifteen pairings. For IGF-1 the folding landscape has two deep minima: the native form and one in which cysteines 6, 47, 48 and 52 are connected differently. The swap isomer forms in meaningful yield during in vitro refolding and is thermodynamically stable, so it does not correct itself. It was characterised in the early 1990s as recombinant IGF-1 processes were developed.
Mass spectrometry of the intact protein cannot see it; the two have the same formula.
Reversed-phase chromatography resolves the two isomers, so the main peak purity figure includes the separation. Peptide mapping under non-reducing conditions identifies which cysteines are joined. A certificate for a refolded protein should state the method that resolves the isomer.
IGF-1 LR3 is supplied by REVIVE LAB UAE for laboratory research use only, with identity and purity documented for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| IGF-1 LR3 Pack | 1 mg | AED 650 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
Two of the bonds, 18-61 and 47-52 in IGF-1 numbering, correspond to the interchain and intrachain bonds of insulin. The third, 6-48, links the B domain to the A domain. Together they hold a compact fold of three short helices. The protein is small enough that the disulfides contribute much of its stability.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.