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The approved recombinant IGF-1 and how it differs from the research analogue

Published 24 October 2026 · REVIVE LAB UAE Research Desk · 5 min read
Mecasermin is recombinant human IGF-1 with the native 70-residue sequence, approved by the United States regulator in 2005 for children with severe primary IGF-1 deficiency, including Laron syndrome and IGF1 gene defects, in whom growth hormone cannot work. It binds the binding proteins normally and enters the ternary complex. IGF-1 LR3 is a different molecule: 83 residues, binding-protein resistant, never submitted for approval for any indication, and supplied only as a research reagent.

What mecasermin is

The product of expressing the human IGF-1 gene in E. coli and refolding to the native disulfide pattern, formulated as a solution. Its indication is narrow: children whose own IGF-1 is absent or whose receptor for growth hormone does not work. In them it restores a signal the body cannot make.

A combination with IGFBP-3, mecasermin rinfabate, was approved and later withdrawn.

How LR3 differs

Sequence: 83 residues against 70. Binding proteins: largely escaped against normally bound. Half-life in circulation: short against extended by the complex. Regulatory status: none against approved for a defined indication. Manufacturing standard: research grade against pharmaceutical grade. The two share a receptor and little else that matters to a regulator.

Calling LR3 a form of IGF-1 treatment conflates the two.

What this page is for

To make the distinction plainly. The existence of an approved IGF-1 does not make the analogue in this catalogue an approved product, and this catalogue does not describe it as one.

IGF-1 LR3 is supplied by REVIVE LAB UAE for laboratory research use only, with identity and purity documented for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.

What it costs

FormatStrengthPriceAvailability
IGF-1 LR3 Pack1 mgAED 650In stock

Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.

Frequently asked

What mecasermin is?

The product of expressing the human IGF-1 gene in E. coli and refolding to the native disulfide pattern, formulated as a solution. Its indication is narrow: children whose own IGF-1 is absent or whose receptor for growth hormone does not work. In them it restores a signal the body cannot make.

Does REVIVE LAB UAE provide dosing guidance?

No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.

How fast is delivery in the UAE?

Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.

IGF-1 LR3 Pack — in stock, dispatched from Dubai
HPLC-verified, lot certificate on every carton, 24-hour delivery nationwide. Browse the catalogue → All peptides UAE

Related reading

→ IGF-1 LR3 Pack — 1 mg → IGF-1 LR3 regulatory status → IGF1 gene deletion in humans

Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.