The gamma subunit has four nucleotide-binding sites of which three are used; AMP and ADP binding changes the conformation so that threonine 172 on alpha is phosphorylated and stays phosphorylated. Calcium, through a second upstream kinase, activates it independently of energy state. Drug-binding sites on the alpha-beta interface are the targets of newer direct activators. There are twelve possible subunit combinations with tissue-specific distribution.
The Hardie laboratory in Dundee has been the main source of this biochemistry since the 1980s.
In one sentence: it turns off ATP-consuming anabolic processes and turns on ATP-generating catabolic ones. Fatty acid synthesis down, fatty acid oxidation up; protein synthesis down; glucose uptake up; mitochondrial biogenesis up over longer periods; autophagy up. In liver it reduces gluconeogenesis and lipogenesis. The phenotype of sustained activation resembles that of exercise training, which is the origin of the exercise-mimetic idea.
Chronic activation is not uniformly beneficial; it also suppresses growth and some repair processes.
Because the MOTS-c mechanism, as proposed, ends at this enzyme, and a reader should know what the enzyme is. This is biochemistry, stated as such.
MOTS-c is supplied by REVIVE LAB UAE for laboratory research use only, with identity by mass spectrometry and purity by HPLC for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| MOTS-c Pack | 40 mg | AED 950 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
The gamma subunit has four nucleotide-binding sites of which three are used; AMP and ADP binding changes the conformation so that threonine 172 on alpha is phosphorylated and stays phosphorylated. Calcium, through a second upstream kinase, activates it independently of energy state. Drug-binding sites on the alpha-beta interface are the targets of newer direct activators. There are twelve possible subunit combinations with tissue-specific distribution.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.