One-carbon metabolism moves methyl groups through folate derivatives and uses them to regenerate methionine from homocysteine and to build purines. Blocking the folate side depletes methionine-cycle output and starves purine synthesis of the one-carbon unit it needs at the AICAR transformylase step, so AICAR accumulates. These are textbook pathways, and the profile reported was consistent with a block at that point.
The same AICAR accumulation is why the folate antagonist methotrexate activates AMPK.
AICAR is taken up by cells and phosphorylated to ZMP, an AMP mimic that binds the regulatory subunit of AMPK and activates it. AICAR has been used as a pharmacological AMPK activator for decades, which is why its accumulation offered a ready explanation for the AMPK activation observed. AMPK in turn promotes glucose uptake, fatty acid oxidation and mitochondrial biogenesis.
AMPK activation by MOTS-c was shown by phosphorylation in cells and in mouse muscle.
The enzyme or process MOTS-c acts on to block the folate cycle has not been identified. The chain from peptide to AMPK is a proposed mechanism supported by metabolomics and consistent with known biochemistry, not a demonstrated binding event. The 2018 nuclear-translocation work added a second, independent mode of action.
MOTS-c is supplied by REVIVE LAB UAE for laboratory research use only, with identity by mass spectrometry and purity by HPLC for the batch. It is not for human or veterinary use, and no dosing, administration or protocol guidance is provided.
| Format | Strength | Price | Availability |
|---|---|---|---|
| MOTS-c Pack | 40 mg | AED 950 | In stock |
Delivery is AED 40 flat and free on orders over AED 700. Payment is cash on delivery anywhere in the UAE, or USDT (TRC20) in advance, which takes 5% off the order total.
One-carbon metabolism moves methyl groups through folate derivatives and uses them to regenerate methionine from homocysteine and to build purines. Blocking the folate side depletes methionine-cycle output and starves purine synthesis of the one-carbon unit it needs at the AICAR transformylase step, so AICAR accumulates. These are textbook pathways, and the profile reported was consistent with a block at that point.
No. REVIVE LAB UAE supplies research materials and provides no dosing, administration or protocol guidance of any kind. Every product is sold for laboratory research use only and is not for human or veterinary consumption.
Stock is held in Dubai. An order confirmed before 4 PM Dubai time is dispatched the same working day, reaching Dubai and Abu Dhabi the same day and the remaining emirates within 24 hours. Delivery is AED 40 flat and free over AED 700.
Supplied for laboratory research use only. Not for human or veterinary consumption. REVIVE LAB UAE provides no dosing, administration or protocol guidance.